Acetyl Hexapeptide - 1

Acetyl Hexapeptide-1 is a potent melanin-regulating peptide used in skin brightening and hyperpigmentation correction formulations. By mimicking the action of the naturally occurring α-MSH (alpha-melanocyte stimulating hormone), it signals melanocytes to reduce excess melanin production, resulting in a more even, luminous skin tone. Ideal for formulators targeting dark spots, post-acne marks, and uneven pigmentation without harsh bleaching agents.

INCI Name: Acetyl Hexapeptide-1

Molecular Formula: C₃₄H₅₅N₉O₉

Alternate Names: Melanostatine-5, MSH Inhibitor Peptide, α-MSH Antagonist Peptide

Purity of the Ingredient: 99%

Country of Origin: India

Benefits and Uses

• Reduces excess melanin production for a brighter, more even skin tone
• Fades dark spots, hyperpigmentation, and post-acne marks
• Gentle alternative to hydroquinone and kojic acid
• Suitable for all skin tones including deeper complexions
• Ideal for brightening serums, spot correctors, and anti-pigmentation creams

How It Works

• Competes with α-MSH at MC1R receptors on melanocytes, blocking melanin synthesis signals
• Downregulates tyrosinase activity — the key enzyme responsible for melanin production
• Works at a cellular signalling level rather than chemically bleaching existing pigment
• Produces a gradual, natural-looking brightening effect with consistent use

pH and Ideal Temperature Range for Best Use

• Optimal pH: 5.0 – 7.0
• Ideal Temperature: Add during the cool-down phase below 40°C (104°F); store refrigerated for extended shelf life

How to Use Acetyl Hexapeptide-1 for Skincare?

• Recommended usage level (pure powder): 0.05% to 0.2% in finished formulation
• Dissolve in a small amount of distilled water before adding to the formulation
• Add to the water phase during cool-down (<40°C)
• Ideal for use in brightening serums, day creams, and spot-correction treatments
• Can be combined with Niacinamide, Vitamin C, or Alpha Arbutin for enhanced brightening effect
• Always perform a patch test before topical application